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Ahmadi Z, Ashrafizadeh M

10.1056/NEJMoa0708857 N

The orientation, identification and bioenergetics of Archaeal membrane-bound nitrate reductases

Introduction For nearly a century, tumors have been found to display metabolic activities that distinguish them from well-differentiated, non-proliferative tissues, which may contribute to their physiological survival and growth ( Glutamine (Gln) is one of the most abundant amino acids in the human body, and its importance as cancer nutrient stems from its ability to contribute its nitrogen and carbon to a range of growth-promoting pathways ( via transporters, and its catabolism begins with conversion to glutamate

Modifications in gene expression occur to yield an increase in the content of HSP [30, 31], proteins that act as molecular chaperones, being crucial in helping the cellular remodelling processes of denatured proteins, independent of the training response [89, 91]