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The separation is probably related to the need to produce compounds derived from glucosinolate hydrolysis under certain conditions

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The second generation (20112018) introduced humanized antibodies, cleavable linkers, and engineered conjugation sites, improving DAR consistency (typically ~3-4) and enabling the use of potent microtubule inhibitors like MMAE and DM1

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Yoon YM, Kim HJ, Lee JH, Lee SH (2019) Melatonin enhances mitophagy by upregulating expression of heat shock 70kDa protein 1L in human mesenchymal stem cells under oxidative stress