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Collagen and Extracellular Matrix Remodeling Much of the dermatologic interest in GHK-Cu stems from its role in the extracellular matrix (ECM)

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GS then catalyzes the second step, consuming another molecule of ATP to add glycine to -Glu-Cys, ultimately forming GSH

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Similarly, cells that are especially dependant on glutamine, such as those in the intestinal mucosa, rapidly undergo necrosis after glutamine deprivation (Lacey and Wilmore, 1990)