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43 In a phase 3 trial including patients with obesity (excluding T2DM), the highest dose group achieved a mean weight reduction of 11.2% by week 72

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In view of the microvascular and macrovascular benefits and long-term legacy effects of early, intensive HbA1c control, it would seem logical to introduce a highly effective agent such as tirzepatide early in the T2D treatment pathway

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At most, one might eventually acknowledge that they feel better compared to an earlier state, but that isnt like seeing a lower weight on the bathroom scale or noticing increases in sustained cognitive effort