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Common side effects of tirzepatide Here is a list of common side effects seen in trials for tirzepatide: Vomiting Constipation Abdominal pain Decreased appetite DIzziness Flatulence/farting GERD Hypersensitivity reactions (such as rash and itching) Indigestion/upset stomach Injection site reactions Mounjaro side effects The most common Mounjaro side effects include: Nausea Diarrhea Abdominal pain Constipation Decreased appetite Indigestion Vomiting Zepbound side effects The most common side effects of Zepbound include: Nausea Diarrhea Vomiting Abdominal pain Indigestion/upset stomach injection site reactions Fatigue Hypersensitivity reactions Belching Hair loss Gastroesophageal reflux disease (GERD) GI side effects are generally manageable and tend to go away the longer you are on the medication