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Of the plethora of articles retrieved from the second MEDLINE search, we identified 28 systematic reviews of animal stud-ies, [39-41] GSH-related genetic polymorphisms linked to various cancers (colorectal can-cer, [42] leukaemia, [43,44] lung cancer,[ 45,46] bladder cancer, [47] gastric cancer, [48,49] prostate cancer, [50-53] adult brain tumours, [54] basal cell carcinoma [55] ) and linked to other disorders (autism, [12, 13] hypertension, 56,57 respiratory diseases, [58,59] cataract, [60] myelodysplastic syndrome, [61,62] glioma [63] and male idio-pathic infertility.[ 64] ) There were 9 RCTs identified from two systematic reviews of the use of GSH to reduce chemotherapy-induced toxicity (6 cisplatin, 2 axaliplatin, 1 platinum)

Although ROS can be generated at several sites of the ETC ( Figure 2

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The duration of immobility was measured by an observer blind to the treatment conditions (Porsolt et al., 1978) after treatment with vehicle, only cannabis (5, 10 or 15 mg/kg, s.c.), fluoxetine, sertraline, imipramine or after cannabis (5 mg/kg) co-administered with the antidepressant drugs