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Ethics declarations Ethical Approval This study is a scoping review of previously published literature and did not involve primary data collection from human participants or animals

General recommendations made without considering individual differences may be misleading

Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow

Given the critical role of neuroinflammation in AD pathology, further research using Lewiss rat models could uncover YSTJs efficacy in modulating microglial activity, reducing pro-inflammatory cytokines, and preserving neuronal integrity

Our study found that kin-19 RNAi in adult worms resulted in several physiological changes consistent with chronic fasting