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Likewise, copper is the cofactor of metabolic enzymes (e.g., cytochrome c oxidase in mitochondria, CuZnSOD in cytosol) and it catalyzes the enzymatic activity of key enzymes of the secretory pathway (reviewed in Polishchuk and Lutsenko, 2013

The slow diffusion of SERF2 in TERRA12 rG4 condensates may be due to strong electrostatic interactions of charged lysine and arginine residues with negatively charged nucleic acid bases, as has been observed for other nucleic acid-binding proteins 90

Additionally, the expression of SLC7A11 decreased, which is another factor contributing to ferroptosis sensitivity

Furthermore, a possible sparing of GSH has been observed with taurine supplementation [89], suggesting indirect redox-balancing roles

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