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A randomized, controlled, blinded human trial of GHK-Cu monotherapy, with a vehicle-only control (and a needling-plus-vehicle arm if a procedure is used), objective endpoints such as blinded global photography and target-area hair counts over at least several months, adequate statistical power, pre-registration, and independent replication

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GHK-Cu plays an important role in tissue regeneration, wound healing, and skin remodeling through multiple mechanisms: it promotes the recruitment and activation of repair cells, enhances the synthesis of extracellular matrix components (including collagen, elastin, and glycosaminoglycans), modulates extracellular matrix turnover by increasing both metalloproteinases and their inhibitors, and exhibits powerful anti-inflammatory and antioxidant effects