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Recent solution NMR structural investigations provide molecular models of p53 transactivation domain interactions with both FOXO4 and senolytic peptides, enabling rational design approaches for next-generation compounds

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However, after 6 months compared to platelet-rich fibrin treatment outcomes, only radiographic bone filling showed significant improvement following BMP-2 application [447]

For malabsorption (e.g., pernicious anemia), injections are often preferred, though some clinicians still use very high-dose oral regimens (NIH ODS)