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The host G-protein coupled receptors (GPCRs), essential for connecting the diet-microbiota-metabolites axis, have predominantly been attributed to the intestinal-metabolite sensing mechanism 29

In vivo experiments of animals with periodontal defect, IGF-1 coated with gelatin particles was significantly more effective in bone formation than IGF-1 isolated in clot

Thus, inhibiting the production and release of ROS and inflammatory cytokines is considered a viable strategy for mitigating LL-IRI

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