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While VGLUT1 helps transport glutamate, the release of glutamate within the synaptic cleft depends on calcium

LOX is a non-heme iron-dependent dioxygenase that can directly oxidize PUFA and PUFA-PLs in membranes, leading to ferroptosis [36]

Beside these senolytic vaccines, other senotherapeutic vaccines intent either to boost the release of anti-aging molecules, or to neutralize other molecules identified as pro-aging factors

Prior to the trial, the older cohort exhibited severe intracellular glutathione deficiency, massive oxidative stress, and impaired mitochondrial function compared to young, healthy controls

Our guide on how long GLP-1 takes to start working covers the typical onset timeline