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Since there is presently no vaccine for Lyme disease that is suitable for human use after the LYMErix vaccine was withdrawn in 2002 due to safety issues and insufficient adoption, there is an urgent need for an effective vaccination to protect at-risk populations

Some important core modifications include histone H3K56 acetylation, histone H3K79 methylation, histone H3T118 phosphorylation, histone H3K122 acetylation, histone H4K59 methylation, histone H4K91 acetylation, and histone H2AK99 methylation among others.

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