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Chronic stress reduces the activity of the neurotransmitter GABA in the hippocampus and PFC, as well as the inhibition of the HPA axis, resulting in anxiety and depression (Mikkelsen et al., 2008)

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Appl Environ Microbiol 89:e0183522

An assessment of the criteria for inclusion, details on the patient population, intervention and control/placebo and clinical outcomes were made as per earlier publications [15]