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In addition to conventional autophagy, macrophages utilize LC3-associated phagocytosis (LAP), a non-canonical mechanism that directly conjugates LC3 to single membrane phagosome-forming structures called LAPosomes, which then mature into phagolysosomes

In a rat myocardial I/R model, AS-IV administration significantly improved left ventricular systolic pressure, FS, and EF, while decreasing left ventricular end-diastolic pressure

This injection technique is designed to maximize efficacy by focusing the drug injections on anatomically safe points

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