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In addition, CISDPI induced an upregulation of the immune checkpoint PDL1 on tumour cells, suggesting an additional benefit when combined with an immune checkpoint inhibitor

In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]