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RNA-sequencing data processing Paired-end RNA-seq data obtained from three biological replicates were analyzed under the conditions of vehicle (Veh), 10 M NAM, 100 M H 2 O 2 , and 100 M H 2 O 2 in combination with 10 M NAM for 4 or 10 days with osteogenic medium in MC3T3-E1 preosteoblasts

There are examples of food-based interventions that have successfully used a food substitution approach to alter multiple components of the diet in a controlled fashion (Reference Weech, Vafeiadou and Hasaj109,Reference Tierney, McMonagle and Shaw110)

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