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Your metabolic engine is running cold

For instance, Edwards et al

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In patients with heart failure, reduced cardiac output and blood redistribution result in decreased intestinal perfusion, leading to ischemia and hypoxia in the mucous membrane of the villous structure of the intestinal wall

Glucose, as a key substrate for energy metabolism, exhibits a concentration gradient in the normal IVD, decreasing from about 5 mM in the outer annulus fibrosus (AF) to about 1 mM in the central nucleus pulposus (NP) (Shirazi-Adl et al., 2010)