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Histopathological hallmarks include focal demyelinated lesions characterized by oligodendrocyte (OL) cell death, axonal damage, gliosis, microglial activation, and infiltration of lymphocytes and macrophages [1,2]

Three days after the last MPTP injection, the mouse striatum was dissected and processed for immunoblotting, qRT-PCR, or GSH assay

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This meta-analysis concluded that there was insufficient evidence to recommend the routine use of inhaled steroids in adults with stable state BE but considered that a therapeutic trial might be justified in patients with difficult to control symptoms

(2024) found that numerous mitochondrial function-related genes, including SQOR, were significantly upregulated in patients with steroid-induced osteonecrosis of the femoral head (SONFH), implicating mechanisms such as dysregulated mitochondrial apoptosis signaling (e.g., BCL-2 / BAX imbalance), increased oxidative stress, and altered energy metabolism