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This implies that TDRKH has roles other than facilitating piRNA trimming, which is consistent with its suggested function of directly attracting MIWI to enable its integration into the piRNA pathway [447,448,449, 454, 455]

471 Mechanistically, reduced NAMPT/NAD + inhibits SIRT1s function, thereby attenuating the deacetylation activity of SREBP1, leading to the expression of ACC and FASN

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