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7 5-Methyltetrahydrofolate is the predominant physiological form of folate and performs the function of converting methionine to SAM

Through effectively attenuating the redox-active Fe 2+ accumulation, decreasing the ferroptotic changes, enhancing the Nrf2-mediated anti-oxidative enzymes expression, reducing the production of key inflammatory factors, and suppressing the caspase 3-dependent apoptotic signaling, ALA remarkably protect the liver function and prevent CSD-induced metabolic deficiency (Figure 7)

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doi: 10.1016/j.juro.2007.03.132

10.1021/acsptsci.4c00545 122 KandhariN.Kraupner-TaylorC