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PLoS One 3: e4032

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A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)

In contrast, the glutathione-activator site remains predominantly uncharacterized except for a highly conserved lysine residue 12

Glutathione (GSH) levels were estimated using a reduced glutathione colorimetric assay kit (Elabscience, USA) (E-BC-K030-S)