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However, the specific antioxidative metabolites produced by metformin-treated microbiota and their anti-IIRI effects have not been fully elucidated

The failure of the antioxidant system to negate the pathological rise in the oxidative species is exacerbated by reduction in levels of the major cellular nucleophile, GSH due to their covalent modification by dopamine quinone species 20,43,44,45