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PLoS One 12 , e0178084 (2017)

In this context, UBCH10 serves as an effector protein target downstream of TNFR1 (Xiao et al., 2022)

45 Melatonin counteracts immunosenescence via a multitarget regulatory network spanning cytokine balance, oxidative stress defense, immune cell functional restoration, signaling pathway crosstalk, disease-specific interventions, and circadian rhythm integration

The advantages of the co-culture model are that it compensates for the shortcomings of the monoculture model, has simple culture conditions and enables high-throughput experiments