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Therefore, it has been observed that the antioxidant capacity found in the cellular matrix may become reduced in critical clinical conditions, including septic shock, cardiac bypass surgery, and reperfusion injury after organ transplantation, and renal dialysis [216]

This suggests potential applications in medical wound care that go beyond the skincare applications most consumers associate with copper peptides, though no copper peptide wound product has completed regulatory approval for clinical wound management

Although steatosis was not confirmed by imaging, 89% would meet criteria for metALD based on reported amount of alcohol consumption (350 gm/week for women and 420 gm/week for men) rather than ALD

The same study revealed that inhibiting HMGB1 down-regulated Bcl-2 and MMP-2 but up-regulated Bax in gastric cancer cells [163]

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