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10.1038/nature09513 Nature 93 DanemanR.ZhouL.AgalliuD.CahoyJ

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Maghsoudi H, Sheikhnia F, Sitarek P, Hajmalek N, Hassani S, Rashidi V, Khodagholi S, Mir SM, Malekinejad F, Kheradmand F, Ghorbanpour M, Ghasemzadeh N, Kowalczyk T

Results vary based on preparation technique and delivery method

When AhR was bound to its agonist, AHR was dissociated from the protein complex and translocated to the nucleus, where it interacted with aryl hydrocarbon receptor nuclear transporter (ARNT) to form a dimer, and activated transcription of target genes by binding to specific enhancer sequences in the regulatory regions of target genes, such as the aryl hydrocarbon receptor response element on the cytochrome P450 Family 1 subfamily B member 1 (CYP1B1) promoter (78)