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Acta Pharm Sin B (2017) 7:3851

PMID: 19332725

Tramadol binds to plasma proteins at about 20 percent (61)

Covalent modifiers: an orthogonal approach to drug design

Treating SCD early enough to prevent disease onset in adult erythropoiesis eliminates the need for lifelong, non-curative treatment and significantly improves the quality of life for both the patient and their family