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Future multicenter double-blind, randomized, placebo-controlled trials in a large and homogeneous sample of patients should focus on higher doses and more prolonged treatment

These results underscore the potential of L-carnitine to enhance reproductive interventions, offering hope for improved outcomes in IVF patients, particularly those with previous IVF failures

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Specific siRNAs for ACBP and/or ALMS1 were reverse transfected at a concentration of 10 nM using Lipofectamine RNAi Max TM Transfection Reagent (13778075, Invitrogen) for 3648 h before treatments