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The absence of functional CFTR disrupts epithelial water and ion homeostasis, leading to the accumulation of dehydrated mucus, recurrent bacterial infections, and ultimately organ failure and other life-threatening consequences [78]

Another common example is in programmed cell death to burn away damaged or useless cells

Conversely, the prevalence of alcohol abuse is approximately fourfold higher among individuals with nicotine dependence [76]

Goodwin has held grants from Servier, received honoraria for speaking or chairing educational meeting from AstraZeneca, BMS, Eisai, Lundbeck, Servier and advised AstraZeneca, Boehringer Ingelheim, BMS, Cephalon/Teva Janssen Cilag, Lilly, Lundbeck, Otsuka, P1Vital, Servier, Shire, Takeda and Pfizer

doi: 10.1101/cshperspect.a003293