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Within the context of PCOS, GPER not only influences the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by regulating the function of the hypothalamicpituitaryovarian (HPO) axis but also improves ovarian function, reduces androgen levels, and promotes normal follicular development and ovulation [156]

The cytochrome c oxidase copper chaperone COX17 (COX17), located on the mitochondrial membrane, can bind with 1-4 Cu + ions

10.1016/j.cellsig.2011.10.018 4 AlloucheS.PolastronJ.HasbiA.HomburgerV.JauzacP

Leaky gut is referred to as increased intestinal permeability in scientific research and is increasingly being recognized as a common underlying factor in most inflammatory symptoms and disorders

(Note: Both vitamin C and niacin are mild acids, which may increase ulcer risk, as well as nicotine elimination and craving in smokers