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Selinexor shows activity in double-hit diffuse large B-cell lymphoma in pre-clinical models and in patients with relapsed/refractory double-hit DLBCL

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As shown in the complex structures of PL pro ubiquitin and PL pro ISG15, SUb1 of SARS-CoV-2 PL pro preferentially binds ISG15 through a different binding mode compared with uniquitin

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But it must be acknowledged that, like heavy metals, excessive concentrations of metal ions from the aforementioned metals can induce various forms of cellular damage and apoptosis, resulting in increased wound inflammation and oxidative stress responses (Song et al., 2019)