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Through the release of cytokines, chemokines, and ECM remodelling factors, CAFs play a crucial role in promoting cancer progression and treatment resistance (27, 4448)

A 2018 Cochrane review article [7] suggested that high-dose (10002000 g/day) oral vitamin B12 replacement may be as effective IM vitamin B12 replacement

10.1016/j.fct.2012.06.010 23 ChangJ.ChiangL.HsuF.LinC

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From that base, providers layer in agents that map onto the physiology above: Fluids and electrolytes a saline base to rehydrate, often with magnesium to replace what alcohol stripped out and to help with headache