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Emdogain (EMD) serves a different but related role in periodontal surgery it re-creates the enamel matrix environment on root surfaces to regenerate lost periodontal attachment, new cementum, and alveolar bone

Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction

However, the repeated or continuous inflammatory and demyelinating processes plus endogenous attempts for remyelination and repair increase vitamin B12 consumption and may lead to its deficiency

This mechanism is sometimes described separately from the angiogenic pathway because it appears to involve protective signalling at the mucosal layer rather than vascularisation per se though the two are not mutually exclusive in research protocols