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[5] These are substantial effects for a naturally occurring tripeptide at physiological concentrations

5.2.2 Ameliorating inflammation and oxidative stress Dihydroartemisinin reduces the expression of TGF-1, a key factor in fibrosis, and inhibits the activation of JAK2 and STAT3, thereby decreasing the expression of the inflammatory factors, such as IL-1, IL-6, TNF-, and chemokine ligand 3, and reducing the infiltration of inflammatory cells (You et al., 2022)

Inflamm Bowel Dis (2024) 8:20814

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Furthermore, it supports investigations into metabolic pathways under controlled laboratory conditions