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Patients acknowledge the importance of screening harms but prioritize early detection as the primary driver of surveillance value

Terminal endpoints included plasma biomarkers alanine/aspartate aminotransferase (ALT/AST), metallopeptidase inhibitor 1 (TIMP-1) and amino terminal peptide of type III procollagen (PIIINP), liver biochemistry, NAFLD Activity Score (NAS), fibrosis stage and quantitative liver histology

However, phytomelatonin levels depend on ripeness stage and postharvest conservation and, in addition, abiotic stressors modulate its production

Mice with increased hepcidin expression showed an increase in total hemoglobin levels and a corresponding increase in red blood cell lifespan, suggesting that hepcidin agonists may help treat abnormal iron absorption in patients with -thalassemia and related diseases

On the other hand, the excessive activation of Nrf2/HO-1 disrupts the balance of iron ion metabolism, leading to ferroptosis [288, 289]