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Nevertheless, the entry of peripheral ghrelin into the brain is limited and potentially binds only to areas of the brain that are less protected by the bloodbrain barrier like the arcuate and the area postrema in the brain stem (Banks et al., 2002

Physiology-Heart Circulatory Physiology 319, H613H631

This knockout also leads to abnormalities in glutamatergic corticostriatal synapses in the striatum, as would be predicted after disruption of an integral component of the postsynaptic structure