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Although antioxidative protection is different from species to species, its presence is ubiquitous (Wachter et al., 2005

Abbreviations CBS: Cystathionine beta-synthase CDF: Cumulative distribution function CTH: Cystathionine gamma-lyase CNV: Copy number variation DEG: Differentially expressed genes FTH: Ferritin heavy chain GC: Gastric cancer GEO: Gene expression omnibus GO: Gene ontology GPX4: Glutathione peroxidase 4 GR: Glutathione reductase GCL: Glutamate-cysteine ligase GSH: Glutathione GSS: GSH synthase HR: Hazard ratios KEGG: Kyoto encyclopedia of genes and genomes MnSOD: Manganese superoxide dismutase MSI: Microsatellite instability MSI-H: High microsatellite instability MSS: Microsatellite stable NC: Negative control NRF2: Nuclear factor erythroid 2-related factor 2 OS: Overall survival PCA: Principal component analysis qRT-PCR: Quantitative real-time PCR ROS: Reactive oxygen species SAAM: Sulfur-containing amino acids metabolism SAAs: Sulfur-containing amino acids siRNA: Small interfering RNA ssGSEA: Single sample gene set enrichment analysis STAD: Stomach adenocarcinoma TCGA: The cancer genome altas TMB: Tumor mutational burden TME: Tumor microenvironment TPM: Transcripts per kilobase million TRX-2: Thioredoxin-2 xCT: Solute carrier family 7 References Bray, F

Iron deposition is frequently observed in ALD, which indicates a potential role of ferroptosis in its development

(2019) showed that PtGSTU19 and U20 isoforms result from a duplication event of a common ancestor of the three species and that a more important divergence has occurred more recently in a common ancestor of P