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These mutations, including p.E256K, p.L315fs, p.R457W, and p.Trp453, disrupt ASCT1 function, impairing L-serine transport and neurotransmitter balance, leading to hypomyelination, cerebral atrophy, and severe neurological deficits 19,22,23

In MASLD, alterations in their activity have been inconsistently reported

The diluent is directed slowly against the inside wall of the vial rather than sprayed onto the powder, and the vial is gently swirled rather than shaken, because vigorous agitation can shear peptide bonds and denature the material

This indicates a delicate balance between the anti-ferroptotic function of the ETS, e.g., mitochondrial CoQH2 production, and the pro-ferroptotic functions, e.g., the production of ROS and ATP