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10.1089/ten.1999.5.127 138 TarnawskiA

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Understanding Vitamin C Dosages The Recommended Dietary Allowance (RDA) for Vitamin C is 90 mg per day for men and 75 mg per day for women, which is generally sufficient for maintaining overall health and preventing deficiency

The assumption that antioxidants exhibit a lag phase and that the length of the lag phase is positively correlated with antioxidant capacity underpins the use of the lag phase

Sterol regulatory element-binding protein 2 (SREBP2) acts as the master transcriptional regulator (129): cholesterol depletion triggers the translocation of SCAP-SREBP2 complex to the Golgi, where proteolytic cleavage releases nuclear SREBP2 (nSREBP2) to upregulate cholesterol synthesis genes (e.g., HMGCR, SQLE), cholesterol sufficiency retains the complex in the ER via SCAP-INSIG binding (130)