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1 Introduction In the contemporary global health landscape, tuberculosis (TB), a persistent challenge, intersects intricately with another widespread condition, diabetes mellitus (DM) ( TB remains one of the major causes of death by a single pathogen worldwide, leading to a global health concern, with the disease affecting around 10 million people each year ( Mycobacterium tuberculosis ( Mtb) and the host, mediated by the inflammatory responses, determines a wide spectrum of clinical presentations