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J Biol Chem (1993) 268(17):122314

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In a randomized, double-blind, placebo-controlled Phase II trial involving 204 patients with mild to moderate plaque psoriasis, daily oral administration of Serlopitanta selective NK1R antagonistled to a statistically significant yet modest reduction in psoriasis-associated pruritus, indicating that NK1R blockade alone may not fully account for the complex mechanisms of itch and that other mediators are likely to play major roles [75]

Patel Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Jenil R

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