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This staggered treatment strategy may be clinically beneficial in maximizing efficacy while minimizing the potential increase in toxicity that might be anticipated from simultaneous co-treatment with two agents

Administration of the Si-based agent significantly alleviated UC inflammation symptoms To examine whether inflammation of the large intestine, the primary symptom of UC, was suppressed by administration of the Si-based agent, MRI of the UC model mice was performed on the 5th day after DSS administration

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This infiltration leads to the release of additional proinflammatory substances, further exacerbating BBB disruption (11, 35, 39)