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In addition, metformin significantly reduced the enhanced HSC activation, proliferation, and migration processes induced by succinate and inhibited the expression of inflammatory cytokines (e.g., IL-6 and TGF-1)

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A mild deficiency may not cause symptoms

This underscores the importance of comprehending and characterizing pluripotent states, including nave and iPSCs, due to their significant implications for research in regenerative medicine and developmental biology