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The 96-well plate was gently shaken for a few seconds and absorbance was read at 340 nm once every minute for 10 min, or to obtain readings at a minimum of 5 time points

Positron Emission Tomography

Mesoporous polydopamine nanoparticles (MPDA-NPs) Mesoporous polydopamine nanoparticles (MPDA-NPs) have a huge surface area and a highly porous structure that allows for effective drug loading and prolonged release of therapeutic drugs like morphine Fig

This process is morphologically marked by small mitochondria with condensed membrane densities, and biochemically by iron overload and GSH depletion, leading to loss of antioxidant defense and irreversible oxidative damage ( 3.2 Key molecular drivers of ferroptosis Iron Overload: Excess intracellular ferrous iron (Fe 2+ ) catalyzes the Fenton reaction, producing hydroxyl radicals (OH) that initiate lipid peroxidation cascades

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