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B.CholujovaD.SchwarczovaZ.SedlakJ.et al (2005)

According to the IUPAC, a pharmacophore represents the spatial and electronic properties required for effective interactions with specific biological targets 23

Author contributions AN: Visualization, Formal analysis, Writing original draft

HIFs modulate gene expression linked to glucose uptake and utilization, angiogenesis, and erythropoiesis [75]

1 Introduction The primary focus of medicine in the late 19 th and early 20 th centuries was the management of communicable diseases (Sakai and Morimoto, 2022)