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The appropriate frequency depends on: Whether you have confirmed deficiency The underlying cause Whether symptoms are present Your personal response to supplementation If you have diagnosed B12 deficiency, treatment should follow medical guidance, including a loading phase and ongoing maintenance depending on the cause

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[DOI] [Google Scholar] 374.Fagundes T.R., Coradi C., Vacario B.G.L., de Morais Valentim J.M.B., Panis C