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Gender and exercise complicate this balance as male nonexercise ME/CFS subjects had higher dimethylglycine and choline levels than their female counterparts and choline was consumed during exercise while glycine, dimethylglycine and phosphorylcholine were elevated postexercise

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doi: 10.1038/s41420-024-02150-9 78 NgCYChanYPChiuYCShihHPLinYNChungPHet al

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Concomitant enzyme inducers: Isoniazid, rifampin, carbamazepine, phenytoin, phenobarbital increase oxidative metabolism