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Clinical studies demonstrate BDNF dysregulation in ASD patients, with preclinical models showing hippocampal neuroprotection upon BDNF administration [27, 28]

In the IBD inflammatory microenvironment, macrophages polarize to the M1 phenotype, characterized by enhanced glycolysis, accompanied by a reduction in pyruvate dehydrogenase (PDH) activity, leading to lactate accumulation and a shift in energy supply mechanisms

doi: 10.1093/hmg/ddaa169 57 NewberryFHsiehSYWilemanTCardingSR

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[DOI] [PubMed] [Google Scholar] 70.Feng R, Dong L