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106 found that patients with acute intrahepatic cholestasis had subnormal serum GGT activity despite high bilirubin levels, suggesting that factors inhibited the release of the enzyme into the blood stream from the liver

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For 24 h experiments, a 10 ml culture (2.5% hematocrit, 34% parasitemia) of ring stage 3D7 or Dd2 strains expressing hGrx1-roGFP2 were treated with antimalarial drugs at 4IC 50 for 24 h

Their specific mechanisms of action can complement small molecule drugs or other biologics to achieve improved therapeutic outcomes

This observation is consistent with previous experimental studies demonstrating the antioxidant potential of esculin in various pathological models, providing mechanistic support for the findings of the present study