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This pathway plays a critical role in mitochondrial quality control, ensuring the removal of damaged mitochondria to maintain cellular homeostasis, especially in high-energy-demanding cells, such as neurons and acinar cells (118)

Association of low plasma antioxidant levels with all-cause mortality and coronary events in healthy middle-aged men from France and Northern Ireland in the PRIME study

Structural basis for Klf4 recognition of methylated DNA

At the level of subcellular compartments, such as the nucleus, mitochondria, lysosomes, endoplasmic reticulum (ER), Golgi apparatus, etc., these perturbations are sensed and activate the corresponding signal transduction pathways to generate the appropriate biological response